In vitro models, such as human reconstructed epidermis or full skin equivalents, are valuable alternatives to animal experiments. Enormous advances have been achieved in establishing skin …

Oct 14, 2024 · In this study we demonstrated that the foreskin-derived skin model can be successfully cultured at room temperature outside a CO2 incubator using a CO2-independent, serum-free media.

Nov 12, 2025 · The goal of this report is to introduce 3-dimensional (3D) immunocompetent skin models for investigating human skin inflammation in vitro to the broader community using primary cells only …

Aug 14, 2025 · Recent advances in bioengineering techniques have enabled the creation of various 3D skin-models with unique characteristics and functions. This paper reviews recent advances in the …

NativeSkin ® models hold the features and functionalities of in vivo human skin, with all cells and appendages, to generate predictive human data. The models only contain real, donated human skin …

Nov 23, 2022 · Human pluripotent stem cells (PSCs) have proven to be invaluable tools for studying human development in vitro.

What are the main findings? Extrapolation from animal skin models poorly predicts clinical outcomes. A spectrum of in vitro human skin models, built from defined cell types and sources, reproduces key in …

Dec 1, 2024 · There are several in vitro approaches to mimicking human skin behavior, ranging from simple cell monolayer to complex organotypic and bioengineered 3-dimensional models. Some have …

Sep 29, 2025 · Skin models are experimental systems that recreate aspects of human skin physiology, function or disease. They include in vitro methods, ex vivo skin cultures and animal models, especially...

Mar 6, 2023 · In this review, we will discuss human skin structures, how these skin structures can be reconstructed in vitro and what is still missing to model human skin in its full complexity.