Integrin subunits span the cell membrane and have short cytoplasmic domains of 40–70 amino acids. The exception is the beta-4 subunit, which has a cytoplasmic domain of 1,088 amino …

By recruiting several proteins that bind actin filaments, the cytoplasmic tails mediate the integrin-cytoskeletal connection, which is essential for most, if not all, integrin mediated functions (see …

Jan 2, 2023 · Integrin functions are dependable on a delicate balance between active and inactive status via multiple mechanisms, including protein-protein interactions, conformational …

May 1, 2020 · Integrins function by bi-directionally transducing biochemical signals and mechanical force across the plasma membrane. This requires engagement of extracellular …

Nov 30, 2023 · The integrin family of proteins consists of alpha and beta subtypes, which form transmembrane heterodimers. Integrins function as adhesion receptors for extracellular …

Integrin-ligand combinations can be clustered into four main classes, based on the nature of the molecular interaction. All five αV integrins, two β1 integrins (α5, α8), and αIIbβ3 recognize …

Results from the initial studies investigating integrin-mediated adhesion and migration led to the hypothesis that integrin activation simply occurred when an integrin receptor came into contact …

Oct 7, 2020 · This review presents current evidence from human and animal studies on integrin structure and molecular signaling, with particular emphasis on signal transduction in infants.

Sep 28, 2022 · Between 2015 to 2020, there were more than 130 clinical trials of anti-integrin therapies — many of which build up on early insights into integrin structure and function. But …

Inactive conformation of integrin (left) and a hypothetical model of the open, active form (right), with a fibrinogen peptide in red and a talin domain in magenta.