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  1. Should I Take Spironolactone for Acne? - Cleveland Clinic Health …

    Dec 28, 2022 · Spironolactone works to clear up hormonal acne by lowering androgen hormones in your body. It’s available as a topical treatment and a pill.

  2. Spironolactone for Acne: How Quickly Will It Work? - Verywell Health

    Oct 28, 2025 · Key Takeaways Spironolactone can take up to five months to show its full effect on acne. Females taking spironolactone must use birth control because it can harm a baby. Take …

  3. Spironolactone for Acne: Dosage, Side Effects & Effectiveness

    Oct 29, 2025 · Learn how spironolactone treats hormonal acne in women. Explore clinical studies, dosage recommendations (25-200mg), side effects, and success rates.

  4. Spironolactone for adult female acne (SAFA): protocol for a double ...

    The study is a phase III, multicentre, double-blind, randomised superiority study, to investigate clinical and cost-effectiveness of spironolactone in the treatment of moderate or severe persistent facial …

  5. Spironolactone for Acne: Side Effects, Effectiveness, and Safety

    Aug 6, 2025 · By blocking certain hormone receptors, the medication decreases your skin's production of sebum, an oily substance that naturally moisturizes your skin but can also clog your pores, leading …

  6. Spironolactone to Treat Acne: What to Know - GoodRx

    Feb 23, 2022 · Spironolactone (Aldactone) is a diuretic (a “water pill”), which means it is a medication that removes fluid from your body through urination. It can be used off-label to treat acne in women …

  7. Spironolactone for Acne: Complete Treatment Guide 2025

    Discover how spironolactone treats hormonal acne with 75-85% success rates. Complete guide to dosing, side effects, and treatment expectations for women.‍

  8. Spironolactone for Acne: Practical Strategies for Optimal Clinical ...

    Jun 30, 2025 · Spironolactone is increasingly used off label for acne treatment and is now being prescribed for women with acne at a frequency similar to oral antibiotics. 1,2 In this article, we …

  9. How Does Spironolactone Work for Acne? - Wisp

    Feb 20, 2025 · Spironolactone works by blocking the hormones that cause oil production, helping your skin stay calmer and smoother. It’s especially helpful for women dealing with acne tied to their …

  10. Assessing Spironolactone's Effectiveness for Acne Treatment

    At its core, spironolactone works by antagonizing aldosterone, a hormone that can increase the production of sebum in sebaceous glands. This reduction in sebum production is instrumental in …