eLife21h
NR2F2 is required in the embryonic testis for Fetal Leydig Cell development
This important study reveals a critical role of the transcription factor NR2F2 in mouse fetal Leydig cell (FLC) differentiation. With elegantly carried out experiments, the authors provide compelling ...
eLife21h
An increase in reactive oxygen species underlies neonatal cerebellum repair
This important work substantially advances our understanding of reactive oxygen species (ROS) as a regenerative signal during postnatal cerebellum repair by activating adaptive progenitor ...
eLife1d
Capsular Polysaccharide Restrains Type VI Secretion in Acinetobacter baumannii
The type VI secretion system (T6SS) is a sophisticated, contact-dependent nanomachine involved in interbacterial competition. To function effectively, the T6SS must penetrate the membranes of both ...
eLife1d
Mechanical imbalance between normal and transformed cells drives epithelial homeostasis through cell competition
Cell competition in epithelial tissue eliminates transformed cells expressing activated oncoproteins to maintain epithelial homeostasis. Although the process is now understood to be of mechanochemical ...
eLife1d
Reconstruction of functional olfactory sensory tissue from embryonic nasal stem cells
During the development of the olfactory epithelium (OE), olfactory sensory neurons (OSNs) express only one member of the odorant receptor (OR) gene family, and O ...
eLife3d
The known unknowns of the Hsp90 chaperone
An exploration of the unanswered questions in how the molecular chaperone Hsp90 supports protein homeostasis, and how single-molecule techniques could drive future breakthroughs in answering them.
eLife4d
Synergistic effect of inhibiting CHK2 and DNA replication on cancer cell growth
By inhibiting the DNA polymerases, BKC enhances the endogenous RS in cancer cells, leading to increased DNA damage. IBC specifically inhibits CHK2 to prevent DNA repair. The combined use of BKC and ...
eLife3d
DNA replication in primary hepatocytes without the six-subunit ORC
The six subunit ORC is essential for initiation of DNA replication in eukaryotes. Cancer cell-lines in culture can survive and replicate DNA replication after genetic inactivation of individual ORC ...
eLife7d
Acetylcholine modulates prefrontal outcome coding during threat learning under uncertainty
This is an important study using a combination of optogenetics and calcium imaging to provide insight into the function of the cholinergic input to the prelimbic cortex in probabilistic spatial ...
eLife11d
Rearrangement of 3D genome organization in breast cancer epithelial - mesenchymal transition and metastasis organotropism
Breast cancer cells exhibit organotropism during metastasis, showing preferential homing to certain organs such as bone, lung, liver, and brain. One potential explanation for this organotropic ...
eLife7d
Female Moths Incorporate Plant Acoustic Emissions into Their Oviposition Decision-Making Process
This study reveals that female moths utilize ultrasonic sounds emitted by dehydrated plants to inform their oviposition decisions, highlighting sound as a potential sensory cue for optimal host plant ...
eLife7d
Neural adaptation to the eye’s optics through phase compensation
This paper shows convincingly that the human visual system can recalibrate itself to compensate for phase alterations in an image induced by optical blur. This phenomenon is studied using state-of-the ...