In a study published in Cell, a research team led by Prof. Li Hanjie from the Shenzhen Institutes of Advanced Technology ...

New research reveals that the immune checkpoint molecule Tim-3 plays a critical role in how microglia, the brain’s immune cells, respond to Alzheimer’s disease.

Tim-3, a molecule involved in immune regulation, hinders plaque removal in Alzheimer’s disease. Blocking it in microglia improved brain health in mice, making it a potential treatment target. Tim-3 is ...

Multi-lineage assembloids incorporate diverse cell types—such as microglia or endothelial cells—to investigate tissue-tissue interactions, like the neuroimmune axis in neurodegenerative ...

Spatial transcriptomics on human brains parsed microglial reactions to amyloid immunotherapy. Both a vaccine and a therapeutic antibody summoned these cells to plaques. Responders expressed TREM2, ...