Blueprint Medicines Corporation focuses on Ayvakit, BLU-808, and Elenestinib with strong potential in mast cell disorders.

A novel cell therapy approach using cord blood-derived natural killer (NK) cells pre-complexed with AFM13, or acimtamig, a CD30/CD16A bispecific antibody, was safe and generated strong response rates ...

Mast cells, which are abundant in the airways of asthmatic individuals, act as first responders to viral infections by producing cytokines, chemokines, and lipid mediators. These immune cells ...

For many patients with diverse and seemingly unrelated symptoms, obtaining an accurate diagnosis can take years of specialist visits and inconclusive tests. Mast cell activation syndrome, a ...

STUART, Fla. — On Friday, a large crowd gathered outside Rep. Brian Mast's office in downtown Stuart. Organizers told WPTV they’re upset over the massive cuts to federal programs and they ...

Results showed the agent lessened severity of cytokine release syndrome or immune effector cell-associated neurotoxicity syndrome (ICANS) for a majority of treated patients. “We expected to see ...

We performed single-cell RNA sequencing on 11 samples of ADC tumor tissues, with other 4 SCC samples served as controls. The immunochemistry and multiplexed immunofluorescence were conducted to ...

Hypoxia modulates inflammatory responses in multiple disease states, including systemic mastocytosis (SM), by influencing mast cell cytokine production, according to results from a study published in ...

In conclusion, Tim-3 was characterized as a novel immune checkpoint molecule with pathophysiological significance in respiratory oncology. Its stage-dependent expression dynamics and multimodal ...

Mast cells have a unique capacity to recognize different molecules and to react to these by releasing specific sets of mediators. Given the great capacity to release powerful mediators, such as ...