An INRS research team has identified a new family of enzymes that can make precise cuts in single-stranded DNA. A few years ...

Most cells in the human body each contain about six feet of DNA. Yet the nucleus, where DNA is coiled, is no larger than a ...

Allison McClure, Ph.D., is an assistant professor in the Department of Biochemistry and Molecular Genetics at the CU School ...

A study links the loss of DNA methylation across the genome—as is common in cancer—to the disruption of the 3-D compartments that organize the genome and to the timing of DNA replication. Cell lines ...

We show that saccharin mediates its antimicrobial activity via bulge-mediated cell lysis rather than through impacting DNA replication dynamics. We reveal that saccharin can inhibit a range of ...

According to the Reddit post, the employee had been addressing the boss by her name for more than a year. However, all of a sudden, she was asked to handwrite the said statement as punishment and ...

FZU - Institute of Physics of the Czech Academy of Sciences, 182 21 Prague, Czech Republic Faculty of Mathematics and Physics, Charles University, Ke Karlovu 3, 121 16 Prague 2, Czech Republic FZU - ...

Department of Life Science, Graduate School of Arts and Science, The University of Tokyo, 3-8-1 Komaba, Meguro-ku, Tokyo 153-8902, Japan Komaba Institute for Science, The University of Tokyo, 3-8-1 ...

Many DNA-damaging anti-cancer drugs cause replication-associated DNA damage that kills cancer cells. This is an effective way of treating cancer, but the problem is that also normal cells are damaged.

PCNA is loaded around DNA by the ATP-dependent clamp loader replication factor C (RFC), which acts at single-stranded (ss)/double-stranded DNA (dsDNA) junctions harboring a recessed 3’ end (3’ ...