Drug-carrying DNA aptamers can deliver a one-two punch to leukemia by precisely targeting the elusive cancer stem cells that seed cancer relapses, researchers report. The aptamers -- short ...
By implementing basic design rules, DNA can be used to form complex nanostructures using the methods of either tiled DNA motifs or DNA origami. When functionalized, these nanostructures can serve as ...
PARP7 is a mono-ADP-ribosyl transferase (mono-ART) which has recently gained attention due to its emerging role as a negative ...
Host cells activate cell death pathways in response to bacterial manipulation of innate immune signalling, but the molecular mechanisms underlying this interplay are not fully understood. This study ...
Key Laboratory of Luminescence Analysis and Molecular Sensing (Southwest University), Ministry of Education, College of Pharmaceutical Sciences, Southwest University, Chongqing 400715, P. R. China ...
Department of Cardiology, Institute for Developmental and Regenerative Cardiovascular Medicine, Xinhua Hospital affiliated to Shanghai Jiaotong University School of ...
Microglia are brain-resident macrophages playing pivotal roles in CNS development and homeostasis. Yet, the cellular and molecular basis governing microglia maintenance ...
by forming an inhibitory complex with heterogeneous nuclear ribonucleoprotein K and DNA methyltransferase 1 at the promoter region of Pitx2, thereby increasing mitochondrial reactive oxygen species ...
All modern humans share DNA from two ancient populations that split 1.5 million years ago and reunited through interbreeding about 300,000 years ago. The genetic mixture is approximately 80% from one ...
This study aimed to encapsulate plasmid DNA encoding the TP53 tumor suppressor gene (pEGFP-N1-TP53) within zeolitic imidazolate framework-8 (ZIF-8) MOFs and ZIF-8-PEI. Subsequently, the transfection ...
The small study in patients with a rare disorder that causes liver and lung damage showed the potential for precisely targeted infusions. By Gina Kolata Researchers have corrected a disease ...
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