A brief look at the Lions’ series history against the Arizona Cardinals, dating back to the Portsmouth Spartans days.

In this week’s NFL power rankings, the general consensus is that the Lions will get the job done. Following a Week 2 loss to the Bucs, experts predict the Lions’ defense, anchored by Aidan Hutchinson, and quarterback Jared Goff — who has struggled over the first two games — will regroup and guide the team to a narrow victory on the road.

The Lions could use a win in Week 3 against the Cardinals. Here are 4 bold Lions predictions ahead of their must-win game in the desert.

See who's in and who's out for the Week 3 matchup between the Detroit Lions and Arizona Cardinals on September 22, 2024.

The Detroit Lions led by DE Aidan Hutchinson bring a similar brand of football to their Week 3 game against the Arizona Cardinals on Sunday.

The 49ers woes in Minnesota continued last week when their former quarterback Sam Darnold torched his old squad. The offense looked like it misses Christian McCaffrey but the defense was surprisingly exposed.

The San Francisco 49ers (1-1) are 6.5-point favorites when they visit the Los Angeles Rams (0-2) in an NFC West matchup on Sunday, September 22, 2024 at SoFi Stadium.NFL odds courtesy of BetMGM

The Arizona Cardinals' Week 3 opponent at State Farm Stadium Sunday afternoon are the 1-1 Detroit Lions, who are favored to win the game. Both teams are 1-1 and both teams' wins came against the L.A.

It's the second-straight season the Lions fell in the second home game of the season, but they will try to get the offense going like the playoff threat it is expected to be.From NFL plays to college sports scores,