Results provide proof-of-concept that ERK pathway reactivation might be an effective, biologically based therapy to prevent anthrax-induced lethality.

"Some of these cells undergo JNK-independent apoptosis (NiA), while others survive and promote proliferation and regeneration ...

Host cells activate cell death pathways in response to bacterial manipulation of innate immune signalling, but the molecular mechanisms underlying this interplay are not fully understood. This study ...

“Some of these cells undergo JNK-independent apoptosis (NiA), while others survive and promote proliferation and regeneration through a novel non-apoptotic function of Dronc in NiCP cells,”. The team ...

This important study provides solid evidence that glucosylceramide synthase (GlcT), a rate-limiting enzyme for glycosphingolipid (GSL) production, plays a role in the differentiation of intestinal ...

These games generally receive all the hype and attention, but there are plenty of other initiatives helping the NFL expand around the world, with the International Player Pathway program being a ...

Chronic exposure to hyperglycemia can lead to cellular dysfunction that may become irreversible over time, a process that is termed glucose toxicity. Our perspective about glucose toxicity as it ...

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Background: Chronic pancreatitis (CP) is a fibro-inflammatory syndrome with unclear pathogenesis and futile therapy. CP’s microenvironment disrupts the fine-tuned balance of macrophage polarization ...

The P/B ratio shows how a stock's market price compares to its book value. It helps gauge whether a stock is undervalued or overvalued relative to its net assets.