The first step in gene expression is called transcription. During transcription, proteins bind to sequences of DNA, such as ...

In some cases, enhancer-promoter interactions only happened when the gene was expressed, so the physical proximity between ...

which allows for greater flexibility in the control of gene expression. As previously mentioned, enhancer sequences are DNA sequences that are bound by an activator protein, and they can be ...

Enhancers can also work independently of one another to direct composite patterns of gene expression when linked within a common region on the same DNA strand. Upon carrying out their study ...

As cells mature and differentiate (right), they use a much more elaborate and cell-type specific ‘switchboard’ to control their gene expression, especially when compared to earlier ...

Researchers discovered that gene deserts, non-coding DNA regions, regulate heart and embryo development through enhancer ...

Enhancer Biology lab studies gene regulation and genome architecture controlled by transcription factors using genome-wide functional genomics methods. Our aim is to understand enhancer malfunction ...

The company's proprietary Synthetic Super-Enhancers (SSEs) are engineered DNA elements that act as docking stations for transcription factors uniquely expressed in aggressive cancer cells. This ...

Genes also contain regulatory sequences, such as promoters and enhancers, which control when and where the gene is expressed. These sequences interact with transcription factors and other regulatory ...

The company's proprietary Synthetic Super-Enhancers (SSEs) are engineered DNA elements that act as docking stations for transcription factors uniquely expressed in aggressive cancer cells. This ...

Transcription activation of genes by estrogens is driven by enhancers, which are often located within the same Topologically Associating Domain (TAD) as non-targeted promoters. We investigated how ...