Mitochondria-mediated apoptosis occurs in response to a wide range of death stimuli, including activation of tumor suppressor proteins (such as p53) and oncogenes (such as c-Myc), DNA damage ...

apoptosis, the planned cellular death mechanism that fails when a cell turns cancerous. Mitochondria are also heavily affected by radiation—they also have DNA, which is separate from the DNA ...

In Ming-Chiu Fung’s immunology lab, Hogan had been investigating how disturbances in the cytoskeletons of cells might contribute to the fragmentation of mitochondria during apoptosis, the most ...

shows that the infection leads to significant transcriptional modification of genes encoding proteins involved in the mitochondrial network, such as the respiratory chain, apoptosis, and the ...

For the first time, researchers have revealed the high-affinity interaction between mitochondrial proteins HAX1 ...

These studies have highlighted mitochondrial dysfunction and oxidative stress as major alterations common to different neurodegenerative diseases. New developments in proteomics, especially for ...