Systemic therapy represents the standard of care treatment for patients with advanced hepatocellular carcinoma (HCC). Given the increased risk of death from cirrhosis-related complications in patients ...

Background Inflammatory bowel diseases (IBDs) are characterised by dysbiosis and a leaky gut. The NADPH oxidase dual oxidase 2 (DUOX2) is upregulated in patients with IBD, yet its role in driving the ...

Department of Medical Sciences and Medical Clinic, University “Amedeo Avodagro” of East Piedmont, Via Solaroli 17, 28100, Novara, Italy Professor E Albano, Department of Medical Science, University ...

Correspondence to Professor Jun Yu, Institute of Digestive Disease, Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, China; ...

Correspondence to Dr Daniela Sia, Division of Liver Diseases, Department of Medicine, Tisch Cancer Institute, Liver Cancer Program, Icahn School of Medicine at Mount Sinai, New York, New York, USA; ...

Objective Both the gut microbiome and host genetics are known to play significant roles in the pathogenesis of IBD. However, the interaction between these two factors and its implications in the ...

2 Department of Pathology, School of Forensic Medicine, Shanxi Medical University, Taiyuan, China 3 Department of Geriatrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science ...

Introduction Hepatitis C (HCV) is a blood borne virus that is curative in over 90% of cases. The NHS England HCV Elimination Programme is working to eliminate HCV in advance of the WHO goal of 2030, ...

Objective This study is to investigate the role of gut dysbiosis in triggering inflammation in the brain and its contribution to Alzheimer’s disease (AD) pathogenesis. Design We analysed the gut ...

Objective Colorectal tumours are often densely infiltrated by immune cells that have a role in surveillance and modulation of tumour progression but are burdened by immunosuppressive signals, which ...

Objective Hepatitis B virus (HBV) can integrate into the chromosomes of infected hepatocytes, contributing to the production of hepatitis B surface antigen (HBsAg) and to hepatocarcinogenesis. In this ...