Applegate's podcast cohost Jamie-Lynn Sigler informed the actress that vomiting and having diarrhea simultaneously is called "double dragoning."

Christina Applegate shared that she thinks her gastrointestinal symptoms are related to multiple sclerosis, explaining, "I get all the pain" from bowel movements.

Christina Applegate shared the toll multiple sclerosis has taken on her body in the form of dozens of hospital visits since her diagnosis four years ago.