Discover 8 ways mast cell activation syndrome causes widespread symptoms from digestive issues to brain fog, often mistaken for other conditions.

It stems from having too many mast cells in the skin, a type of white blood cell involved in the immune system. Understanding ...

If so, you probably noticed that scratching made the rash much worse. But scratching an itch, especially one as intense as ...

Mast cells, which are abundant in the airways of asthmatic individuals, act as first responders to viral infections by ...

In a case report published in the World Journal of Oncology, an elderly female patient was diagnosed with mast cell leukemia (MCL), with imaging showing extensive osteoblastic metastatic lesions. MCL ...

underscoring the importance of treating patients early in the ISM disease course -- -- BLU-808 healthy volunteer trial results demonstrate wide therapeutic window for modulating mast cell activity ...

At the recent AAAAI/WAO meeting, Blueprint Medicines Corp. presented the in vitro and in vivo characterization of BLU-808, a selective inhibitor of wild-type KIT, a transmembrane receptor tyrosine ...

Langerhans cells, mast cells, monocytes and macrophages, neutrophils and NK cells. Macrophages can recycle nutrients and metabolites from bacteria that they phagocytose. New work is showing how ...

BLU-808 achieved dose-dependent serum tryptase reductions exceeding 80 percent, reflecting evidence of mast cell target engagement. BLU-808 had a half-life supporting once-daily oral dosing and ...