The Hokies look to win against a ranked opponent for the first time since 2021 with No. 16 Louisville coming to Blacksburg.

Preview the Week 10 NCAA football matchup between the Louisville Cardinals and Virginia Tech Hokies with best bets, picks, predictions and more.

The Virginia Tech football program was built on defense under Frank Beamer and Bud Foster. The defense has fallen off after the Beamer regime ended, and the Hokies’ identity doesn’t seem to have the same blue-collar mentality Beamer built in Blacksburg.

With the matchup a couple days away, we have our first inclination as to who could play, and will not. On Thursday, the ACC released the first availability report for Louisville's matchup vs. Virginia Tech. An updated report will come out at 8:00 p.m. EST on Friday, and a final report will then be released two hours before kickoff.

College football Week 10 odds, picks, predictions, TV channel, streaming for Louisville Cardinals vs Virginia Tech Hokies ACC game Saturday, Nov. 1.

Virginia Tech is another. However, for the right head coach, it's one of the best jobs available. The Hokies used to be a perennial power in the ACC, even reaching the BCS National Championship game when Michael Vick was the quarterback.

Virginia Tech football has now released its initial player availability report to the ACC for its Week 9 bout vs. California. 14 Hokies were listed as out on the report, two were questionable and one was probable. Here's the full list, with the full report included below:

Why did Virginia Tech football's Brent Pry era not work out and what should the Hokies look for in a new coach? As VT's coaching search approaches November with a crowded 2025-26 FBS carousel, 247Sports surveyed established high school coaches from the region.

Any member of Tech’s eight-person search committee with a preconceived notion of who the next coach should be is doing the process a disservice.

In a jaw-dropping moment during Virginia Tech's thrilling double-overtime victory over California, the Hokies were stung by one of the most egregious

Kickoff from Lane Stadium in Blacksburg, Va., is at 7:30 p.m. ET. The Hokies are 6.5-point favorites in the latest California vs. Virginia Tech odds, while the over/under for total points scored is 50.5. Before making any Virginia Tech vs. California picks, check out the college football predictions from the SportsLine Projection Model .

Virginia Tech Women's Basketball head coach Megan Duffy spoke with the media on Tuesday afternoon for the first time since the ACC Tipoff in Charlotte, three weeks ago. With the Hokies' first game exactly a week away, these were the three biggest takeaways from her press conference: