CpG density and epigenetic modification state modulate DNA mechanics, altering its intrinsic compatibility with nucleosome formation.

Reconstructed image of the basic unit of chromatin, the nucleosome. Nucleosomes link together like beads on a string, connected by stretches of linker DNA. To form a condensate, these strings bind ...

DNA–protein cross-links (DPCs) represent a severe form of DNA damage that can disrupt essential chromatin-based processes. Among them, DNA–histone cross-links (DHCs) occur frequently within ...

Individual cells divide through a process called mitosis, during which the cell's copied DNA is separated between two resulting daughter cells. Despite recent advances in cell biology, the mechanism ...