In some of the more severe cases morphologic study has also disclosed intrahepatic cholestasis. 6. In the 4 cases reported below, ... There was evidence of necrosis of renal tubular cells.

Six patients had overt evidence of gastrointestinal hemorrhage; in 2 it was severe. ... The necrosis is limited to the mucosa, the muscular layer is intact, and there is no serosal reaction.

These data indicate that "prolonged [TNF inhibitor] treatment plays a protective role in PsA development in severe psoriasis ...

Severe acute pancreatitis is driven by a systemic inflammatory cascade and pancreatic necrosis resulting in organ failure; it accounts for higher mortality — up to 20% vs. 1% in mild cases ...

Hydrogen gas pockets, produced by gas-forming organisms, arise in the submucosa and subserosa. Severe necrosis may completely obliterate the villi (Fig 3A and B). (Enlarge Image) ...

TNF-α inhibitors may reduce mortality and inflammation in moderate-to-severe COVID-19 cases. However, further studies are ...

Operative necrosectomy has been the standard of care for bacterial infected necrosis of the pancreas. In the absence of established guidelines for pancreatic fungal infection, the same should be ...