In some of the more severe cases morphologic study has also disclosed intrahepatic cholestasis. 6. In the 4 cases reported below, ... There was evidence of necrosis of renal tubular cells.

Six patients had overt evidence of gastrointestinal hemorrhage; in 2 it was severe. ... The necrosis is limited to the mucosa, the muscular layer is intact, and there is no serosal reaction.

These data indicate that "prolonged [TNF inhibitor] treatment plays a protective role in PsA development in severe psoriasis ...

Severe acute pancreatitis is driven by a systemic inflammatory cascade and pancreatic necrosis resulting in organ failure; it accounts for higher mortality — up to 20% vs. 1% in mild cases ...

Hydrogen gas pockets, produced by gas-forming organisms, arise in the submucosa and subserosa. Severe necrosis may completely obliterate the villi (Fig 3A and B). (Enlarge Image) ...

TNF-α inhibitors may reduce mortality and inflammation in moderate-to-severe COVID-19 cases. However, further studies are ...