Predicting a protein's structure from its amino acid sequence is a 'holy grail' for the structural biology community. In spite of decades of effort, it remains an extremely difficult problem both ...

Researchers have unveiled the first real look at a mitochondrial protein strongly linked to Parkinson's disease, revealing ...

Because a protein’s structure helps determine its biological function, the new structures, along with those available from cryo-EM, could revolutionize biology and drug discovery. To be useful ...

The protein "MIPS" changes its internal structure when it becomes active. Its disordered active center becomes a defined structure with special functions. The protein plays a key role in the ...

The sequence of amino acids in the chain determines how the chain will fold up to make the protein, so different proteins have different three-dimensional shapes. The three-dimensional shape of a ...

Rohini Subrahmanyam is a biologist-turned-science-writer with a background in neuroscience and developmental biology. She has written ... nanoseconds to microseconds for a protein to morph along its ...

Priyom Bose holds a PhD in plant biology and biotechnology from the University of ... 7 However, artificial intelligence (AI) has substantially improved protein structure prediction based on amino ...

As such, their structure can generally be ... oligomorphism in computationally designed protein assemblies, Nature Structural & Molecular Biology (2025). DOI: 10.1038/s41594-025-01490-z ...

With the long-term goal of creating living cells from non-living components, scientists in the field of synthetic biology work with RNA origami. This tool uses the multifunctionality of the natural ...

"AlphaFold has transformed structural biology by providing accurate predictions of protein structures ... accurately predict the three-dimensional structure of IDPs, it can predict the distances ...