Chemotherapy for pediatric acute lymphoblastic leukemia (ALL) induces rapid and durable alterations in cerebrospinal fluid (CSF) metabolism, and a lipid-rich CSF signature measured early in treatment ...
Decades before a person's first memory problems surface, changes happen in their biofluids that suggest their path toward dementia has already been forged. Two studies identified proteomic signals, in ...
- Nature Medicine publication describes how GENESIS trial included patients representative of current multiple myeloma population undergoing autologous HSCT, including older patients and those who ...
A commercially available plasma phosphorylated-tau217 assay was highly accurate in identifying Alzheimer disease pathology. The plasma phosphorylated tau (p-tau) at threonine 217 (p-tau217) ...
With amyloid immunotherapy in clinical use, scientists need to find better ways to identify the patients most at risk of developing ARIA (see part 16 of this series). One of the biggest danger signs, ...
Exploring the genetic blueprint of cerebrospinal fluid proteins, this study uncovers new markers and therapeutic targets that may unlock advancements in Alzheimer’s diagnosis and care. Study: ...
Long before memory problems appear, your brain may already be losing neurons. That is the unsettling message from new work by scientists at the University of Colorado Anschutz Medical Campus, who ...
CSF-ctDNA was detected in 59% of cases and showed high concordance (84%) with tumor mutations. Lower variant allelic frequency in CSF-ctDNA was associated with significantly worse survival outcomes.
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