Penn State vs Ohio State picks, predictions for college football Week 10 game Saturday

College football Week 10 odds, picks, predictions, TV channel, streaming for Penn State Nittany Lions vs Ohio State Buckeyes Big Ten game on Nov. 1.

WATCH: Ryan Day previews Ohio State vs. Penn State game Saturday at the Shoe

The Buckeyes renew their rivalry with Penn State Saturday at noon on Fox 28. Ohio State looks to extend momentum after a 34-0 win; Nittany Lions seek rebound.
Doc's Sports

Penn State Nittany Lions vs Ohio State Buckeyes Prediction, 11/1/2025 College Football Picks, Best Bets & Odds

Ohio Stadium is where the Ohio State Buckeyes (7-0) will attempt to defeat the Penn State Nittany Lions (3-4) on Saturday, November 1, 2025. Ohio State opens this game as 20.5-point favorites. The total comes in at 43.5.
ABC27

3 takeaways from Terry Smith’s Week 10 press conference ahead of Ohio State game

Penn State interim head coach Terry Smith spoke on the Nittany Lions’ upcoming matchup with the top-ranked Ohio State Buckeyes on the road in a weekly press conference. The bye week

Ohio State Makes Urban Meyer Announcement for Saturday's Game vs. Penn State

Urban Meyer will have a special role at Saturday's gameThe Buckeyes have a date with Penn StateMeyer's record in Columbus was sensational The Ohio State Buckeyes' 2025 schedule was predicted to be one of the tougher ones in the nation consider a trio of marquee games against Texas and Penn State at
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