Microglia are brain-resident macrophages playing pivotal roles in CNS development and homeostasis. Yet, the cellular and molecular basis governing microglia maintenance ...

Suppressing microglia can also be effective, but systemic depletion of microglia typically weakens immunity, making the body ...

We hypothesized that the lack of microglia in the FIRE mice would cause deficient myelination during early development, an idea in line with results from previous studies that used global macrophage ...

But not all microglia are created equal. Some are quite effective at removing plaques, while others struggle, the study found. Also, microglia in treated brains adopt distinct states depending on ...

Suppressing microglia can also be effective, but systemic depletion of microglia typically weakens immunity, making the body more susceptible to infections. "To address this limitation ...