Colossal Biosciences leaders say the fluffy, golden-haired mice help validate their technique to “de-extinct” species, but ...

Within the cell, NOVA1’s job is to bind to RNA to regulate alternative splicing—a process by which exons from the same gene are assembled in different ... to determine whether the human NOVA1 impacted ...

De-extinction startup Colossal Biosciences has gene-edited mice to have mammoth-like features, creating what the company calls the Colossal Woolly Mouse. The lab mice, which have been modified to ...

A gene-edited woolly mouse (left) beside a typical lab mouse. Provided by Colossal Biosciences. Instead, researchers identified the genes that gave mammoths their distinct look, then identified ...

Alternative splicing plays a pivotal role in defining cell phenotypes and physiology in multicellular eukaryotes, often distinguishing between cell types more accurately than gene expression. 1 During ...

“This gene is part of a sweeping evolutionary ... The study, “A humanized NOVA1 splicing factor alters mouse vocal communications,” was published in Nature Communications in February 2025.

This method offers both single-base resolution for annotation and 'digital' gene expression levels at ... start sites as a measure of coverage in mouse embryonic cells, and demonstrated that ...

At first I was looking for the word GENE to be split. There was a nice "Aha!" moment when I realized it was the genetic material DNA undergoing the SPLICING. It's always interesting to have ...

Alternative splicing (AS) of pre-mRNA plays a crucial role in tissue-specific gene regulation, with disease implications due to splicing defects. Predicting and manipulating AS can therefore uncover ...