The first step in gene expression is called transcription. During transcription, proteins bind to sequences of DNA, such as ...

In some cases, enhancer-promoter interactions only happened when the gene was expressed, so the physical proximity between ...

Trogenix Unveils Revolutionary Platform to Transform Cancer Treatment Through Precision Viral ImmunotherapyCompany founded by 4BIO Capital and ...

As cells mature and differentiate (right), they use a much more elaborate and cell-type specific ‘switchboard’ to control their gene expression, especially when compared to earlier ...

Researchers discovered that gene deserts, non-coding DNA regions, regulate heart and embryo development through enhancer ...

The company's proprietary Synthetic Super-Enhancers (SSEs) are engineered DNA elements that act as docking stations for transcription factors uniquely expressed in aggressive cancer cells. This ...

The fluorescent glow of mouse brain cells on the right indicates the effectiveness of a human-derived gene enhancer, HAQER0059, versus a 6 million year old version of the enhancer at left ...

Transcription activation of genes by estrogens is driven by enhancers, which are often located within the same Topologically Associating Domain (TAD) as non-targeted promoters. We investigated how ...

Cancer genomics is the study of the totality of DNA sequence and gene expression differences between ... of gene promoters with cognate enhancers is both predictive of and rate-limiting in neoplasia.

Such modifications can alter gene expression and therefore the properties ... This prevents premature enhancer activation, which is crucial for gene regulation and lineage specification.