Excess cellular cholesterol induces apoptosis in macrophages, an event likely to promote progression of atherosclerosis. The cellular mechanism of cholesterol-induced apoptosis is unknown but had ...

The peripheral endoplasmic reticulum (ER) forms a continuous, dynamic network of tubules that plays an important role in protein transport and quality control, cellular signaling, and stress response.

The endoplasmic reticulum is the protein-making factory within cells consisting of tightly stacked sheets of membrane studded with the molecules that make proteins. Now, researchers have refined a new ...

Aberrant proteins are extremely harmful to cells. Such proteins can originate from mutations, unbalanced subunit synthesis, damaging conditions (for example, oxidation) and also as a side product of ...

Improvements in public health have allowed humankind to survive to older ages than ever before, but, for many people, these added golden years are not spent in good health. Aging is a natural part of ...

How these shapes arise, however, is largely a mystery. Harvard Medical School cell biologists have now cracked the code for part of the endoplasmic reticulum (ER), a protein - and fat-making organelle ...

Cancer drugs are often designed to block specific molecular targets, but what happens after they enter a cell is not always ...

The body's cells change their shape to close gaps such as wounds – with part of the cell flexing depending on the curve of the gap and the organization of cell-internal structures, a new study reveals ...

Textbook drawings of the cell’s largest organelle might need to be updated based on new images. Super-resolution shots of the endoplasmic reticulum reveal tightly packed tubes where previous pictures ...

A team of scientists has answered a long-standing question in cell biology, uncovering how the cell’s main energy currency, ATP, is transported into the endoplasmic reticulum (ER). Disrupted energy ...