Sickle cell disease is a genetic disorder that causes lifelong suffering—here's what you need to know
Sickle cell disease changes adult beta-globin. Instead of two alpha and two healthy beta chains, sickle cell disease patients have two alpha and two mutant beta chains. The resulting hemoglobin is ...
Nature2y
Sickle-Cell Anemia: A Look at Global Haplotype Distribution
Sickle-cell trait haplotype distribution shows ... Unlike adult hemoglobin, FH consists of two α-globin chains and two γ-globin chains. In utero, FH is the major constituent of fetal RBCs ...
Medscape3y
Therapy Insight: Stroke Risk and Its Management in Patients With Sickle Cell Disease
The causative mutation is the substitution of valine for glutamic acid at the sixth position of the β globin chain (Glu6Val). Sickle cell hemoglobin (HbS) behaves like normal hemoglobin when ...