was also associated with the DISC in cells stimulated to undergo apoptosis in a way that is dependent on CUL3. Although p62 acts downstream of caspase-8 ubiquitination, it is important for its ...

Apoptosis is regulated by a family of cysteine-aspartyl proteases (caspases) that are activated ... of ischemia-reperfusion injury 7, burns 8, endotoxemia 9 and sepsis 10 after administration ...

Caspase Related Reagents Courtesy of Bingren Hu, Queen's Medical Center, Hawaii. Provided by Cell Signaling TechnologyConfocal micrograph of double immunostaining for cleaved caspase-3 (green) and ...

Scientists commonly use caspase assays to evaluate apoptosis, evaluating caspase activation—a hallmark of apoptosis initiation—with fluorescent dyes. Researchers often perform multiplex caspase assays ...

Macrophages control intracellular pathogens like Salmonella by using two caspase enzymes at different times during infection.

This focus has evolved to include the investigation of non-apoptotic functions of proteins that have long been considered to have roles in apoptosis, the caspase family of proteases. Our research ...

Dronc refers to Drosophila initiator caspase, a protein involved in apoptosis and other developmental processes, and which has previously been documented as promoting proliferation in a process called ...