ascopubs.org

First-in-human, phase 1a dose finding of LVGN6051 CD137/4-1BB agonistic antibody with or without pembrolizumab in patients with advanced solid tumors.

A phase 1 study of AGEN2373, a novel CD137 agonist antibody designed to avoid hepatoxicity, in patients with advanced solid tumors. This is an ASCO Meeting Abstract from the 2023 ASCO Annual Meeting I ...
ascopubs.org

Efficacy, safety, and PK/PD of LVGN6051, 4-1BB agonistic antibody, with pembrolizumab in a phase Ib dose expansion in resistant NSCLC, melanoma, and GI malignancy.

Targeting a non-canonical STING signaling pathway in T cells to improve antitumor immunity. This is an ASCO Meeting Abstract from the 2024 ASCO Annual Meeting I. This abstract does not include a full ...
GEN

Metastatic Cancers Eliminated by CD40 Agonistic Antibody

Over the past 20 years, a class of anticancer drugs called CD40 agonist antibodies has shown great promise but also induced great disappointment. While such drugs have been effective at activating the ...
Animal Welfare Institute

Southwick, C. H. 1967. An experimental study of intragroup agonistic behaviour in rhesus monkeys (Macaca mulatta). Behaviour 28, 182-209.

A significant increase in agonistic behavior occurred when the distribution of the food was restricted, but the amount of food remained normal. Highly significant increases in the frequency of ...
Animal Welfare Institute

Bolt, L. M. 2021. Agonistic vocalization behaviour in the male ring-tailed lemur (Lemur catta). Primates 62(2), 417–430.

Vocalizations are used by group-living animals as aggressive and submissive signals during agonistic interactions, and are also used to maintain dominance hierarchies in many species. For gregarious ...