The two discussed Israel and Iran for 50 minutes, with Mr Putin pushing for Russia’s proposal to resolve concerns about Tehran’s nuclear program, according to a readout from Russian official Yuri Ushakov.

The Iranian and Israeli strikes mark the most sustained, direct attacks ever between the two rivals. Three people were killed in Israel and at least 78 in Iran, officials said.

There have been more explosions tonight in Tehran and Tel Aviv as the conflict between the Mideast foes escalates following Israel’s unprecedented attack early Friday. Follow our live updates.

Iran crossed "red lines" when it fired missiles at civilians in Israel, Israeli Defense Minister Israel Katz said in a statement Friday evening. Israeli Prime Minister Benjamin Netanyahu said "more is on the way," in a statement Friday evening when talking about Israel's attacks on Iran.

The attacks, which Israel said targeted Iran’s nuclear program and military targets, killed Maj. Gen. Hossein Salami, head of Iran’s Islamic Revolutionary Guard Corps.

The retaliatory strikes came after Israel attacked Iran, killing top military leaders and scientists. The assault destroyed an aboveground nuclear enrichment plant near Natanz, the head of the U.N. nuclear watchdog agency said.